Seoul National University
The mechanical and physical properties of cells, such as mass, volume, density, and stiffness, are essential for understanding the state and function of living cells. Changes in these cellular properties play a pivotal role in various biological processes, including cell movement, development, differentiation, and disease progression (e.g., cancer metastasis). In this talk, I will introduce a Mechano-Physical profiling technique that precisely measures the mechanical and physical properties of individual living cells. This technique utilizes a Suspended Microchannel Resonator (SMR), a vibrating cantilever with embedded microfluidic channels. By analyzing changes in resonance frequency as cells pass through embedded channel, the SMR can precisely quantify the mass, volume, density, and stiffness of single cells. Lastly, I will discuss applications in cell development and cancer growth, leveraging insights from these single-cell measurements.